My slightly fantasy-esque wishlist, in order of importance:
(EDITED: wishes already coming true in green)
Refine the on-ball defense further, get rid of 'magnetic' defenders,
'psychic' pass interceptions by defenders with their backs to the play, and the unrealistic/exaggerated bumping or stagger animations.
New animations.
Fake passes WHILE going for a layup.
Manual bounce passes.
Iceman's finger roll as a floater shot?
Bring back the walking the ball upcourt animation, the omission of it was ridiculous in the first place. This is the wish that is most likely to come true (already has in the demos, as far as the walking the ball animation goes).
More customizability:
-create-a-layup&dunk-package
-
create-a-sig-jumpshot, by mixing and matching the take off->hangtime->release->follow through->landing animation sections.
-create-a-crossover/spin move/hesitation-package
-manually assignable emotional/celebrational animations (a.k.a Kobe and J. Terry's 'airplane' move, Steph Curry's 'three' move, Kobe&Vujacic's 'boxing' move with each other, etc).
-More options with your custom team's jerseys/name/logo/stadium/court/coach's appearance etc.
-
More CAP options. If I'm not mistaken a really old NBA 2k (forgot which one, I think it was the one with Iverson on the cover) had customizable body proportions: head size, shoulder width, arm length, etc.
Ability to play a blacktop game in My Player mode (controlling only your player, of course)
at any time.
More informal/street courts. Hoping for a custom court mode like NBA street/FIFA street (forgot which one) would be too much. Remember the China, snowy, beach, Egypt (might be mixed up on this one with another game) courts in older NBA 2ks?
More realistic head and body proportion for players.
A more festive on-court celebration when you win the championship, like in the Winning Eleven/PES games.
A 'voice pitch' option/slider for your MyPlayer, like in RPGs, so your 300 pound white/Asian center doesn't always sound like a trim African American.
Less lame secrets/easter eggs. 
in older sports / NBA Live games we can get sunglasses, hoodies, even weird playable characters. Would be nice entertainment value at the least

NBA 2k11+all that=the perfect basketball game of all time IMO
