A common issue modders creating (and users using) Total Conversions encounter, is the inability to keep the original game and the total conversion installed without having to copy the entire game folder to another place, or keeping manual backups of any files the mod replaces.
Another common issue for users, is downloading a mod and installing it, only to find out they didn't like it, but not having kept a backup, they have to dig up their original disc to find the original file, or download another mod.
The solution to all this is JSGME. JSGME, or Generic Mod Enabler, is a mod manager that works with any game. You install it to the game's installation directory, and put any new mod you want to try in a subfolder within a Mods folder. JSGME will detect the mods in that folder on start-up, and allow you to enable any of them.
It automatically keeps backups of your original files and restores them when you disable the mod. It also detects if a mod you're about to enable will conflict with another enabled mod. It can also keep mod profiles that remember which mods you want enabled for each profile (e.g. a Classic profile, in which you'll have classic courts, a classic scoreboard, classic jerseys, etc).
You can download it here: http://www.gamefront.com/files/20963192/jsgme_setup_exe

Video Tutorial
Tutorial
1. Install it to your NBA 2K12 installation folder.
2. You'll find a MODS subfolder created inside now.
3. For every mod you want to be able to enable and disable, create a subfolder inside the MODS folder, with the name of the mod. For example, if you want to be able to switch between the TNT and NBA TV scoreboards, create two folders like so:
...\NBA 2K12\MODS\TNT Scoreboard
...\NBA 2K12\MODS\NBA TV Scoreboard
4. Extract the files of each mod into those subfolders, not into your installation path directly.
5. The mods will show up on JSGME, and you can enable/disable them.
Here are some screenshots to help you:



Credits to JoneSoft for this great tool.
The Gamefront link doesn't work anymore, so here's another link by Benuydere.
Benuydere wrote:http://www.mediafire.com/?bxb8lnfaep3bgpj
Just copied this from viewtopic.php?f=149&t=90401 so all credits to Sir Leftos.