We'll need a bit more information than that. Have you recently installed any new patches? Do you get an error message when the game crashes? And finally, does it crash at a specific time or when you use a specific team/player?
PATCHES: ESPN HD NLSC V.25 NEW COURTS(i dont remember) A cyberface patch for KOBE oh and i cant move at all during game so i change the configuring controlls but it still dont Work
I would try removing all the patches (move them to another folder so you can restore them later on if you like) and see if the game crashes. If it doesn't, then it points to a problem with one of the patches you've got installed, in which case you can try adding the patches again (a few at a time, if you like) until you run into problems. That way, you can pinpoint the problematic patch (or patches).