I got a desktop last December with these specs:
Intel E2200 2.2GHz Dual Core

nVidia GeForce 8500GT 512MB DDR2 128-bit
a 160GB SATA Hard Drive, by Seagate perhaps
4GB DDR2 of Kingston RAM
An ASUS Motherboard, SATA-enabled
An ATX casing with 550W power supply.
...
and a generic DVD writer.
I get to install and run Fallout 3, Mass Effect, NBA 2K9, Burnout Paradise and Oblivion well enough. That is until last Tuesday, when my younger brother was playing Fallout 3. He told me that the game suddenly ran slowly, like your friendly FPS drops. And when he restarted F3, it didn't run until the third try.
It was like Fallout was running smoothly for 5-10 minutes and it will lag like that.
So I guess it was just the game, as I've reinstalled it, updated the game to v1.4 and added the DLC's. It's still the same. I reinstalled the graphics driver and it's still the same. I checked on Burnout Paradise and it's the same as Fallout now. The game runs smoothly at first then the FPS gets whacked.
Wonder what in hell got wrong.